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Publication

Title:De-Peptidising Protein-Protein Interactions – big jobs for small molecules
Authors:Fayne, D., 2013
Abstract: Virtually all biological processes rely on protein–protein interactions (PPIs) for signal propagation, therefore representing a vast array of potentially viable therapeutic intervention points. Targeting PPIs is a relatively novel drug development strategy so computational approaches towards analysing the interface between protein partners and predicting the likelihood of developing a small molecule inhibitor are still progressing. This review provides an overview of recent successful examples of computational methodologies used to predict druggable PPIs and small molecules designed to inhibit them.
ICHEC Project:Study of Weak Interactions in Protein-Ligand Models using Quantum Mechanical Calculations to Aid the Design of Novel LXRalpha Modulators.
Publication:Drug Discovery Today: Technologies, Volume 10, Issue 4, December 2013, Pages e467-e474, ISSN 1740-6749, http://dx.doi.org/10.1016/j.ddtec.2013.08.002.
URL: http://www.sciencedirect.com/science/article/pii/S1740674913000486
Status: Published

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