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Dr. Simon Wong

Simon Wong

Dr. Simon Wong
PhD
Computational Scientist
E-mail:
Tel: +353 1 5241608 (ext 25)

Simon holds an undergraduate degree in Human Genetics from Trinity College Dublin, where he also completed his PhD in Prof. Ken Wolfe's lab at the Genetics Department. His PhD work covered a range of topics including whole genome duplication, evolution of yeast mating types and selection for a specific gene cluster in anaerobic yeast species. He then held a postdoctoral position in Prof. Mark Ragan's lab at The University of Queensland in Brisbane, Australia, where he developed a method to classify protein subsequence families and was involved with projects dealing with large-scale protein-protein interaction & subcellular localisation datasets.

He joined ICHEC as a computational scientist in 2008 and is primarily involved in supporting the bioinformatics/life sciences community. He is active in introducing researchers to ICHEC resources and ways to gain access. For ongoing projects he provides consultation and hands-on assistance for setting up bioinformatics analyses and workflows, which employ a wide range of software packages on ICHEC systems. Simon also collaborates with scientists on various research projects, e.g. microRNA target prediction. One of his main research interest lies in tackling computational challenges posed by high-throughput DNA sequencing technology, where he has been actively involved in nematode transcriptome analyses and has supported users in carrying out metagenomic studies. Simon is also involved in the Irish BioPortal project, which aims to provide a resource to highlight Irish bioinformatics software, as well as a more general platform for bioinformatics researchers to run compute-intensive applications on HPC resources.

Apart from scientific and user support activities, Simon manages ICHEC's Education and Training programme, which includes provision of training courses and workshops for academia and industry, accredited graduate teaching and student mentorships. In the FP7 PRACE-2IP project, a pan-European collaboration involving HPC centres from >20 countries and a budget of €35.4M, Simon leads the Training work package where the centres work together to provide training resources for European researchers.


Publications

Perry A., O'Hurley G., Raheem O.A., Brennan K., Wong S., O'Grady A., Kennedy A.-M., Marignol L., Murphy T.M., Sullivan L., Barrett C., Loftus B., Thornhill J., Hewitt S.M., Lawler M., Kay E., Lynch T. and Hollywood D. (2013) Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer. International Journal of Cancer 132:1771-1780.

Tyson T., O'Mahony Zamora G., Wong S., Skelton M., Daly B., Jones J.T., Mulvihill E.D., Elsworth B., Phillips M., Blaxter M. and Burnell A.M. (2012) A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags. BMC Research Notes 5: 68.

Bustamam A., Sehgal M.S., Hamilton N.A., Wong S., Ragan M.A. and Burrage K. (2009) An efficient parallel implementation of Markov clustering algorithm for large-scale protein-protein interaction networks that uses MPI. In Proceedings of the 5th IMT-GT international conference on mathematics, statistics and their applications 2009 (ICMSA 2009), Bukittinggi, Indonesia, pp. 94-101.

Shin C.J., Wong S., Davis M.J. and Ragan M.A. (2009) Protein-protein interaction as a predictor of subcellular location. BMC Systems Biology 3:28.

Wong S. and Ragan M.A. (2008) MACHOS: Markov clusters of homologous subsequences. Bioinformatics 24:i77-85.

Scannell D.R., Byrne K.P., Gordon J.L., Wong S. and Wolfe K.H. (2006) Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts. Nature 440:341-345.

Wong S. and Wolfe, K.H. (2006). Duplication of genes and genomes in yeasts. In Comparative genomics (Sunnerhagen P. and Piskur J., eds.), Vol. 15, pp. 78-99. Springer-Verlag, Heidelberg.

Wong S. and Wolfe K.H. (2005) Birth of a metabolic gene cluster in yeast by adaptive gene relocation. Nature Genetics 37:777-782.

Logue M.E., Wong S., Wolfe K.H. and Butler G. (2005) A genome sequence survey shows that the pathogenic yeast Candida parapsilosis has a defective MTLa1 allele at its mating type locus. Eukaryotic Cell 4:1009-1017.

Wong S., Fares M.A., Zimmermann W., Butler G. and Wolfe K.H. (2003) Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata. Genome Biology 4:R10.

Wong S., Butler G. and Wolfe K.H. (2002) Gene order evolution and paleopolyploidy in hemiascomycete yeasts. Proceedings of the National Academy of Sciences, USA 99:9272-9277.